What is the mode of action for Propofol?

Propofol acts primarily by interacting with GABAa receptors in the central nervous system. This interaction enhances the inhibitory effects of GABA, a neurotransmitter that plays a crucial role in reducing neuronal excitability throughout the brain. When Propofol binds to the GABAa receptor, it increases the influx of chloride ions into neurons, leading to hyperpolarization of the cell membrane. This hyperpolarization decreases neuronal activity, resulting in sedation, anesthesia, and anxiolysis.

Understanding the mechanism of action of Propofol is essential for its use in clinical settings, as it allows healthcare professionals to predict its effects on consciousness, sedation levels, and its role in inducing and maintaining anesthesia.